The SCN4B protein modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.The protein has been found to be expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart.
Immunohistochemistry analysis of paraffin-embedded mouse brain using SCN4B (GB111596) at dilution of 1: 2000
Immunohistochemistry analysis of paraffin-embedded rat heart using SCN4B (GB111596) at dilution of 1: 2000
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