The gene may function as a general inhibitor of the histone deacetylase HDAC1.The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. Overexpression of this gene interfered with MAP3K12 induced apoptosis.
Western blot analysis of AATF (GB111594)
at dilution of 1: 1000
Lane 1: Mouse heart tissue lysate
Lane 2: Mouse kidney tissue lysate
Lane 3: Mouse thymus tissue lysate
Lane 4: Mouse placenta tissue lysate
Lane 5: Rat heart tissue lysate
Lane 6: Rat kidney tissue lysate
Lane 7: Rat thymus tissue lysate
NOTE: This product is intended for research only.