GADD45GIP1 acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity.
Western blot analysis of CRIF1 (GB111592)
at dilution of 1: 1000
Lane 1: Mouse lung tissue lysate
Lane 2: Rat liver tissue lysate
Lane 3: Rat spleen tissue lysate
Lane 4: Rat lung tissue lysate
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