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  • Anti -2B4 Rabbit pAb

    货号:GB111427

    品牌:Servicebio

    价格:¥650

    规格: 100 μl

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    Product Information

     

    Description
    2B4 rabbit polyclonal
    Protein full name
    Natural killer cell receptor 2B4
    Synonyms
    NK cell type I receptor protein 2B4, NKR2B4, Non-MHC restricted killing associated, SLAM family member 4, SLAMF4, Signaling lymphocytic activation molecule 4, CD244, 2b4, Nmrk
    Immunogen
    Recombinant protein corresponding to
    Mouse 2B4
    Isotype
    IgG
    Purity
    Affinity purification
    Predicted MW.
    45 kDa
    Observed MW.
    60 kDa
    Uniprot ID

     


     

    Applications

     

    Applications
    Species
    Dilution
    Positive Tissue
    WB
    Human, Mouse, Rat
    1: 500-1: 1000
    lung, lymph node, spleen, thymus

     


     

    Background

     

    CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome.

         


     

    Images

     

    Western blot analysis of 2B4 (GB111427)
    at dilution of 1: 1000
    Lane 1: Jurkat cell lysate
    Lane 2: Mouse lung tissue lysate
    Lane 3: Mouse lymph node tissue lysate
    Lane 4: Mouse spleen tissue lysate
    Lane 5: Mouse thymus tissue lysate
    Lane 6: Rat lung tissue lysate
    Lane 7: Rat lymph node tissue lysate
    Lane 8: Rat thymus tissue lysate

     


     

    Storage

     

    Storage
    Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
    Storage Buffer
    PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

     


     

    NOTE: This product is intended for research only.

     

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