CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome.
Western blot analysis of 2B4 (GB111427)
at dilution of 1: 1000
Lane 1: Jurkat cell lysate
Lane 2: Mouse lung tissue lysate
Lane 3: Mouse lymph node tissue lysate
Lane 4: Mouse spleen tissue lysate
Lane 5: Mouse thymus tissue lysate
Lane 6: Rat lung tissue lysate
Lane 7: Rat lymph node tissue lysate
Lane 8: Rat thymus tissue lysate
NOTE: This product is intended for research only.