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  • Anti -GPR161 Rabbit pAb

    货号:GB111421

    品牌:Servicebio

    价格:¥650

    规格: 100 μl

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    Product Information

     

    Description
    GPR161 rabbit polyclonal
    Protein full name
    G-protein coupled receptor 161
    Synonyms
    Gpr161, Gm208, RE2, G protein coupled receptor RE2
    Immunogen
    KLH conjugated Synthetic peptide
    corresponding to Mouse GPR161
    Isotype
    IgG
    Purity
    Affinity purification
    Predicted MW.
    60 kDa
    Observed MW.
    65 kDa
    Uniprot ID

     


     

    Applications

     

    Applications
    Species
    Dilution
    Positive Tissue
    WB
    Mouse, Rat
    1: 500-1: 1000
    heart, brain

     


     

    Background

     

    GPR161 (also known as RE2) is an orphan G protein-coupled receptor and plays important roles in the Hh pathway. In the absence of Hh signals, GPR161 localizes to primary cilia and keeps the downstream GLI transcription factors in their repressor forms . Ciliary localization of GPR161 requires TULP3 and the IFT-A complex. In presence of SHH, GPR161 is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling.

         


     

    Images

     

    Western blot analysis of GPR161 (GB111421) at dilution of 1: 1000
    Lane 1: Mouse heart tissue lysate
    Lane 2: Mouse brain tissue lysate
    Lane 3: Rat heart tissue lysate
    Lane 4: Rat brain tissue lysate

     


     

    Storage

     

    Storage
    Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
    Storage Buffer
    PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

     


     

    NOTE: This product is intended for research only.

     

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