corresponding to Mouse GPR161
GPR161 (also known as RE2) is an orphan G protein-coupled receptor and plays important roles in the Hh pathway. In the absence of Hh signals, GPR161 localizes to primary cilia and keeps the downstream GLI transcription factors in their repressor forms . Ciliary localization of GPR161 requires TULP3 and the IFT-A complex. In presence of SHH, GPR161 is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling.
Western blot analysis of GPR161 (GB111421) at dilution of 1: 1000
Lane 1: Mouse heart tissue lysate
Lane 2: Mouse brain tissue lysate
Lane 3: Rat heart tissue lysate
Lane 4: Rat brain tissue lysate
NOTE: This product is intended for research only.