The PDE10A plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides，eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.
Western blot analysis of PDE10A (GB111420) at dilution of 1: 1000
Lane 1: Mouse brain tissue lysate
Lane 2: Mouse testis tissue lysate
Lane 3: Rat brain tissue lysate
Lane 4: Rat testis tissue lysate
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