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  • Anti -Constitutive androstane receptor Rabbit pAb

    货号:GB111418

    品牌:Servicebio

    价格:¥650

    规格: 100 μl

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    Product Information

     

    Description
    Nr1i3 rabbit polyclonal
    Protein full name
    Nuclear receptor subfamily 1 group I member 3
    Synonyms
    Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67, Nr1i3, Car, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3
    Immunogen
    Recombinant protein corresponding to
    Mouse Nr1i3
    Isotype
    IgG
    Purity
    Affinity purification
    Subcellular location
    Nucleus, Cytoplasm
    Predicted MW.
    41 kDa
    Observed MW.
    41 kDa
    Uniprot ID

     


     

    Applications

     

    Applications
    Species
    Dilution
    Positive Tissue
    WB
    Mouse, Rat
    1: 500-1: 1000
    liver
    IHC
    Mouse, Rat
    1: 500-1: 1000
    liver

     


     

    Background

     

    This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs.

         


     

    Images

     

     




    Western blot analysis of Nr1i3 (GB111418)
    at dilution of 1: 1000
    Lane 1: Mouse liver tissue lysate
    Lane 7: Rat liver tissue lysate





    Immunohistochemistry analysis of paraffin-embedded mouse liver using
    Nr1i3 (GB111418) at dilution of 1: 800

    Immunohistochemistry analysis of paraffin-embedded rat liver using
    Nr1i3 (GB111418) at dilution of 1: 500

     


     

    Storage

     

    Storage
    Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
    Storage Buffer
    PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

     


     

    NOTE: This product is intended for research only.

     

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