This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs.
Western blot analysis of Nr1i3 (GB111418)
at dilution of 1: 1000
Lane 1: Mouse liver tissue lysate
Lane 7: Rat liver tissue lysate
Immunohistochemistry analysis of paraffin-embedded mouse liver using
Nr1i3 (GB111418) at dilution of 1: 800
Immunohistochemistry analysis of paraffin-embedded rat liver using
Nr1i3 (GB111418) at dilution of 1: 500
NOTE: This product is intended for research only.