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  • Histone H3(兔抗)

    货号:GB11026

    品牌:Servicebio

    价格:¥650

    规格: 100μl

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    Product Information

     

     

    Description

    Histone H3.3 rabbit polyclonal

    Protein full name

    Histone H3.3

    Synonyms

    H3F3A, H3.3A, H3F3, H3 histone, family 3A, H3 histone family member 3A

    Immunogen

    KLH conjugated Synthetic peptide corresponding to Mouse Histone H3.3

    Isotype
    IgG
    Purity
    Affinity purification

    Predicted MW.

    15 kDa

    Observed MW.

    15-20 kDa

    Uniprot ID

     


     

    Applications

     

     

    Applications

    WB

    Species

    Human, Mouse, Rat

    Dilution

    1: 1000

    Positive tissue

    Hela, Jurkat, liver cancer, lung, brain

     


     

    Background

     

     

     

    Histone H3.3 is a protein that in humans is encoded by the H3F3A gene.Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

                 


     

    Images

     

     

    image.png
     

    Western blot analysis of Histone H3.3 (GB11026) at dilution of 1:1000.

    Lane 1: Hela cell lysate

    Lane 2: Jurkat cell lysate

    Lane 3: RAW264.7 cell lysate

    Lane 4: Human liver cancer tissue lysate

    Lane 5: Mouse lung tissue lysate

    Lane 6: Mouse brain tissue lysate

    Lane 7: Rat lung tissue lysate

    Lane 8: Rat brain tissue lysate

     


     

    Storage

     

     

    Storage
    Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
    Storage Buffer
    PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

     


     

    NOTE: This product is intended for research only.

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